Some of the side effects possible with trazodone treatment include constipation, headache, drowsiness or blurred vision. For more specific information, consult with your doctor or pharmacist for. Trazodone Trazodone HCl (generic Desyrel) is a modified cyclic antidepressant used as a treatment for depression. It may also be used for relief of an anxiety disorder (e.g., tension, sleeplessness), chronic pain or to treat other conditions as determined by your doctor. As Trazodone can cause dizziness, drowsiness and blurred vision, your doctor will advise you not to drive or use machinery until these symptoms pass. If you smoke marijuana, you should tell your doctor, as smoking marijuana or drinking alcohol can increase the dizziness which is sometimes experienced when taking Trazodone. Other flulike symptoms are also very common, such as fever, fatigue, chills, slight headache, runny nose, and mildly blurred vision. Some individuals may experience issues with shakiness and balance, or have mild tremors in their hands. Trazodone (generic name: Desyrel ) increases the amount of a brain chemical called serotonin and is indicated for the treatment of major depressive disorder. Trazodone (generic name: Desyrel ) increases the amount of a brain chemical called serotonin and is indicated for the treatment of major depressive disorder. Trazodone is approved by Health Canada for the treatment of depression in adults. Health Canada has not approved Health Canada has not approved trazodone for the management of sleep difficulties or for use by children and adolescents. Trazodone is an antidepressant medicine. It affects chemicals in the brain that may be unbalanced in people with depression. Trazodone is used to treat major depressive disorder. In Summary. Commonly reported side effects of trazodone include: blurred vision, dizziness, drowsiness, headache, nausea, vomiting, and xerostomia. Trazodone is approved by the FDA as a prescription drug used for the medical treatment of depression. Learn about side effects, drug interactions, dosages, warnings, and more. Learn about side effects, drug interactions, dosages, warnings, and more.